The chromosome substitutes the shoulder

If we do not help, then many cancer patients will be without a chance to survive: the state has never financed the work of hospital laboratories in full.

The main thing is that everyone he will affect: acute leukemia will defeat and win absolutely, but it is impossible to do this at the funds allocated by the state. The state slyly pretends not to know this, and continues to finance only individual pieces of a huge process. In some cases, the only way of salvation is the bone marrow transplantation (TCM), and it seems to me that everything that is associated with TCM is the absolute triumph of science and its complete international. The Advita Foundation from St. Petersburg is one of those who help science to triumph, and people-recover and return to normal life. “I believe that we are human rights activists,” says Elena Gracheva, administrative director of Advita. “We protect the human right to access the chance to survive.”
We will defeat the leukemia, and we will win absolutely, but it is impossible to do this at the funds allocated by the state Twist this quote

The chance to survive begins with the search for a donor, and the state does not intend to pay for this search, money for search - modest 18 thousand euros - the patient must contrive and find himself. The crazy, for a complete gap of aorta, is running around, the running of relatives of a dying person in search of money, funds and sponsors begins. The state does not notice all this point blank and continues to behave as if donors are on every corner and beg to take bone marrow from them ... Of course, if there is a donor in Russia, the cost drops sharply, but their number is ridiculous - only 35 thousand people. In Germany, for comparison, six million.

And there are only three clinics in which TCM are made. And only in one of them - to all patients, regardless of age. This is the Research Institute of Pediatric Oncology, Hematology and Transplantology named after R. M. Gorbacheva in St. Petersburg. It is to him that the Advita fund helps him.

Outwardly, the search for the donor looks very simple: the doctor enters the Internet on the international register (this is a world base, which contains the data of 22 million bone marrow donors), introduces the necessary parameters, and the computer immediately shows which country the potential savior of someone’s life lives. In general, the register is such a fantastic international science, it gives an incredible feeling of the unity of the world. Here is an example: the bone marrow of only one single person came up to a resident of Kazakhstan. And this man lived in Australia. In general, on the same planet. The main thing is that he was in the register. And Kazakh was saved.

With me, too, the data of one patient was introduced like this - it turned out that six strangers can help him - in the USA, Portugal, Brazil, Germany, France and Cyprus!

But this is only the first step. Each of these six should be physically found (and many donated blood a few years ago), make sure that they still want to help, completely indulge, that is, see tissue compatibility with the patient (and this is a combination of 10 four -digit numbers), deliver the donor to the clinic, take bone marrow from him and send the recipient.

He does not intend to spend its funds on all this state.

It turns out that in Russia many die from leukemia not because the disease is incurable, but because there is no money even for the very first step. “Of course, there could be much more donors from Russia, but we do not have any educational work on this topic at the state level, everyone does only funds,” explains Elena Gracheva. “What can I say if most people still confuse the bone marrow with the dorsal.

In Russia, many die from leukemia not because the disease is incurable, but because there is no money even for the very first step. Twist this quote

Another universal misconception is also amazing: supposedly the bone marrow transplant is incredibly painful, extremely harmful to the donor and occurs with the obligatory participation of a surgical saw - in general, you will remain disabled. In fact, this is completely wrong.

There are two ways to take the bone marrow: a short surgery (iliac penet) or a three -hour cell fence on a blood separator, during which it is driven through a centrifuge. The bone marrow is a liquid, which is almost not distinguished from the blood, just the most it is in the bone cavity, hence the name. The charm and value of the bone marrow is that only in it are hematopoietic (stem) cells. Here they are, these cells with a romantic name, and give rise to all other blood cells. The rotation speed of the centrifuge is designed in such a way as to allow to separate hematopoietic cells from others and only take them.

I saw how the bone marrow was taken on the separator, and then, just a couple of hours later, I watched the reddish-brown liquid slowly flowed into the vein of the recipient, returning his life.
This was happiness. Almost like at the birth of a child.

What is behind these two events? The command work of doctors from the most diverse laboratories of the Research Institute of the Research Institute of Dog named after R. M. Gorbacheva. Work that few people know about, and the indispensability of which few, except for specialists, represent.

Here, for example, immediately after the fence, the bone marrow, now called the transplant, enters the cryoconsection laboratory. There they consider the number of stem cells - the success of transplantation largely depends on this. But you can see these cells only with the help of special reagents - monoclonal antibodies (ILO), which are also needed when making a diagnosis, as they allow doctors to recognize whether a healthy cell or a patient is healthy in front of them. One bottle with a MOT costs at least 30 thousand rubles, but at least ten tests are required for accurate diagnosis. The state has never completely financed these studies.

The name of another laboratory speaks for itself - transplantation and molecular hematology. Studies are performed here that help to make the prognosis of the disease and evaluate the effectiveness of therapy. That is, they look here not only how the tumor leaves, but also how the donor material is engaged, how healthy donor cells are displaced by patients-and this happens differently in each case.

“We are studying the genetic breakdowns characteristic of most oncological diseases,” explains Ildar Barkhatov, candidate of medical sciences and head of the laboratory. “And with modern treatment methods, we can prescribe highly effective targeted therapy (from the English word Target -“ goal ”, approx.“ Such deeds ”) that will affect exclusively on tumor cells, not affecting the healthy ones.” And adds in such a meaningless voice: "We can identify one sore cell of ten thousand."

Incredible cosmic accuracy!

In 2014, 8,864 studies were performed in the laboratory of transplantology and molecular hematology. Most of them financed the Advita fund. The state also added something, but somehow very delicately.

Here I can’t resist, so as not to tell my favorite story about the sixth chromosome.
The sixth chromosome is such a small wand-seed with a coquettishly intercepted belt overweight. Small, of course, to say wrong. Correctly - invisible, about six hundred times smaller than the ant. Well, the average ant is about six hundred times less than a person. Introduced? Great. So, part of the chromosome above the high waist is called a short shoulder. In this shoulder there are genes that are responsible for cell compatibility during bone marrow transplantation. To everyone who was cured of leukemia through transplantation, the sixth chromosome set his shoulder. I like it when the chromosome substitutes the shoulder to a person.

Probably the longest shoulder in his entire life.

Everyone who at least once tried to raise funds for charity will say with confidence that they are most willing to help children (even more willing to girls with blue eyes and blond hair). For test tubes, laboratory research and other people do not want to give boring turbidity. My friends! A tubes are saved lives, and not distant research and not even space flights. There will be a test tube - there will be a person! This must be very clearly understood in connection with the transplantology of bone marrow. Without analyzes, doctors turn into casts and go by touch.

Test tubes are saved lives, not distant research Twist this quote

The scientific world is unusually harmonious. Alas, it depends not only on the flight of thought, but also on money. It seems to everyone that the state should give to test tubes. Of course, it should. But it does not give or gives not in full. Just accept it as a fact. And if we do not help Advite, then nothing will save a small blond girl, nor many many people.

And if someone scornfully says “test tubes”, do not believe it! Do not believe for anything! A tubes are life. No TKM is done without test tubes. Not a single patient recovered without their participation.

PS. It is not at all difficult to become a bone marrow donor. To begin with, you just need to pass 20 milliliters of blood. All details can be found here . You just want to!

I remind you that the donation of bone marrow around the world is free, anonymous and voluntarily. And so it will always be.

Yes, that's what else. Do you know what the guy called his donor, who was poured with bone marrow with me and returned life? He called him "Bratun"!

So.

PPS. Monologue of the mother of the recipient.

“When my son was diagnosed for the first time, I physically felt that life was over, I stopped living. It is necessary to eat - this stomach demanded, and not me, I have to sleep - the body asked. I came to my son in the hospital - I smiled, of course, and from him I went home - tears of the river. Do not stop. She lived without any hope, she felt worse than he, because they told me more than him, and I understood what could be ahead. Then everything seemed to cost, there was remission. And suddenly - relapse. We were immediately warned that the treatment would be very serious, ahead - a transplant. I was even worse than the first time. After all, now additional obstacles have stood on the way to recovery: or not chemotherapy will help whether there is a donor, whether we will find funds for him, and whether they will take us to the clinic. The failure at any of the stages is the end. And time worked against us. There was such a confusion - in words not to describe. There is no life further. It all ended.

We gathered a family council at home - my sister, a son of a son and her parents came. And they offered to make a VKontakte support group. And I didn’t even understand what it was about, I was stuck in the Soviet Union, but, of course, grabbed this straw. Well, my sister and I have our whole small city along and across the announcements with a cry for help.

How many people have responded! An unfamiliar woman called, she had a daughter with Down syndrome, offered 20 thousand. I say: “What are you, you have your own child,” and she in response: “You can’t save my child, let you help you.” We also went to all kinds of rich organizations - but only the rich on the threshold, basically, were not allowed. In Gazprom, I remember, they said that they were insolvent, but a huge number of completely unknown citizens supported us in small amounts. But it turns out who did not collect the money, dies ... I just can't believe it ...

We found a donor in a month - it was such a miracle incredible! Yes, even in Russia!

From time to time, all sorts of stupid thoughts climb into the head-suddenly a group of blood will change when part of another person will go to him, whether I will still be his mother, or he seems to be no longer mine ... I, of course, drive these thoughts, but they still climb ... ”

She, dressed in a red dressing gown and a mask, silently spent the whole transplant in the corner of the chamber on a chair, and when it ended, she went to her son busily and began to measure his pressure.

It was normal.