There is already a vaccine?!

Yes, it is not from coronavirus, but can suspend pandemia and protect doctors

How would you react if you found out that the coronavirus vaccine already exists? That she is more than 60 years old, she costs 10 cents, is accepted orally (swallow one drop - and that’s all), has practically no side effects, and that billions of people around the world are vaccinated with it? Meanwhile, all this is probably true.

We are talking about a "living" polio vaccine. But with one significant reservation: this vaccine does not give 100% immunity against Covid and does not give it forever. It simply increases the body's natural immunity by several weeks, radically reducing the likelihood of infection. It is easy to imagine how important it is, for example, for a doctor in these critical several weeks of epidemics, so that doctors do not get sick, and hospitals do not become nursers of infection.

The fact that the “living” vaccines stimulate the innate immune system and protect not only from the disease against which they are directed, but also give a short -term increase in immunity, transferring the entire body to the protective regime and forcing it to produce proteins that suppress the reproduction of any virus has long been known.

From the very beginning, the epidemic was remembered and talked about BCG - a “living” vaccine for tuberculosis. BCG, however, is far from the best vaccine: it protects from tuberculosis, by current standards, not very good, and gives complications.

However, we have much more reliable than BCG, a candidate. This is the same polio vaccine, which has been used around the world for a long time, and in developing countries it is still used. In addition to the fact that it protects against poliomyelitis, but also reduces 30% child mortality from other infections in developing countries. When the OPV was used in Europe, mortality, of course, did not decrease (there was nothing to decline), but the frequency of visiting a doctor decreased.

In the 1970s, an experiment was put up in the USSR. An epidemic of influenza was approaching the country, and workers were instilled at the Gorky Automobile Plant on several conveyors, and at one - they did not do this.

The vaccinated conveyors continued to work, and the control had to be stopped - everyone fell ill. The decrease in the incidence was 75%.

OPV helped against influenza better than the antifungal vaccine itself.

OPV has an amazingly interesting fate. It was created by the American virologist Albert Sein, but they began to use it in the USSR. This was done by a partner and colleague Sabina, the most prominent Soviet virologist Mikhail Chumakov. The case took place in the 1950s, shortly after the death of Stalin, and the OVP was an amazing case of cooperation between the two superpowers in the midst of the Cold War: a sort of Soyuz-Apollo from virology.

Poliomyelitis - now exterminated both in the USA and in Russia - had a pandemic scale, causing panic fear of all parents. This is a highly visible disease that affects mainly children, which causes polyovirus, which is released in a huge number with feces. It gets into the mouth usually through contaminated water. For the most part, the disease is asymptomatic, but in about 0.5% of cases the virus penetrates the central nervous system and affects motor neurons, which leads to partial or complete paralysis. There is no treatment for Polio.

At the beginning of the XX century. polio has become one of the worst childhood diseases -

In New York alone, in 1916, 2000 children died from him. At the age of 39, the future American President Franklin Delaino Roosevelt fell ill with polio at the age of 39: he was paralyzed and moved in a stroller.

Roosevelt's disease played a huge role in the fight against Polio. In 1938, the President founded one of the most influential American paramedicine NPOs - National Foundation for Infantile Paralysis, now more known as March of Dimes. These - and many other efforts - led to success, and in 1955 the American virologist Jonas Solk from the University of Pittsburgh, after two million tests at schoolchildren throughout the country, received the approval of the FDA for the production and application of the first vaccines against Polio in the history of humanity.

The vaccine was a "dead" vaccine. Its basis was a virus killed by formalin. She gave excellent results,

Jonas Solk turned into the Savior of the nation and incredibly rich.

Meanwhile, the Solol had a colleague and an opponent - Albert B. Seibin from the University of Cincinnati. Unlike the Sun, Seiner tried to create a “live” Vaccine from Polio, believing that such a vaccine would give a more reliable and lifelong immunity. Solk and Seibin, how easy it is to guess, hated each other. Seibin envied the sensational success of Solol, and Solk was furious when he put Seibin as an example, calling him a real scientist, unlike the “inflated PR man” Solk, whose scientific achievements were rather modest and boiled, as his enemies said, to the ability to knock out money to work that any student-medical student could perform. It is interesting that both scientists came from the same environment: parents and Solol and Seibin were poor Jewish immigrants from tsarist Russia.

By 1955, Seibin finally made his “live” vaccine, but there could be no question of testing it in the USA. By this time, Solk was the number one hero, his word, his word was the law-and he was ready to block Sabbin oxygen, where he was possible. The number of people on whom the Seibin vaccine was tested was calculated by the hundreds, including volunteers of the confinced, Seibin himself and his family, but Seybin needed millions tests.

It was then that Albert Seinin, a native of the town of Bialystok, Grodno province of the Russian Empire, son of Jacob Sapershtein and Tsili Krugman, who arrived in the USA in 1921, when he was 15 years old, made a truly unexpected move.

He turned to the head of the United States, the totalitarian power, who also suffered from polio and could in a centralized order to instill millions of children. The two largest Soviet virus of that time were Anatoly Smorodintsev and Mikhail Chumakov. Seibin brought the first batch of his vaccine to the USSR in a suitcase. She was instilled in the first group. “I was also among these vaccinated,” recalls the son of Chumakov Konstantin.

The Soviet Ministry of Health was suspicious of this venture, suspecting that the Americans sent a vaccine to the USSR, which they themselves did not want to use. Mikhail Chumakov made his way to a high boss office, picked up the “turntable” pipe and called Anastas Mikoyan.

"Do you believe in this vaccine?" - asked Mikoyan. "Yes". Mikoyan ordered: "vaccinate."

Thus began this unprecedented Union-Appleon. By 1959, Chumakov pressed 10 million Soviet children vaccine, and a few months later the entire population of the USSR under 20 was vaccinated. Graduate stations were everywhere - in hospitals, schools, and kindergartens. Cost a penny vaccine in comparison with the vaccine of the Soon; No sterile syringes were needed. “At the Babaev factory they made a sweet dragee with a vaccine, and the children swallowed it with a dragee,” recalls Konstantin Chumakov.

Polio in the USSR was eliminated, and after this, WHO recognized the vaccine safe and began to widely use it in developing countries. Already much later it turned out that from this vaccine in very rare cases (about one per million) there are complications in children who are disturbed by immunity. For those who have immunity, the vaccine is completely safe.

In 1986, the American Sabin received the Soviet Order of Friendship of Peoples. As for Mikhail Chumakov, the system did not forgive him with a obstinate character and a call over the head of Minister Mikoyan; All of his projects were rejected one after another, ten million doses of the measles vaccine he had developed were destroyed in the autoclave, and the system was especially rigidly put on the tests that are most important for us: the possibilities of using the OPV against seasonal epidemics by temporarily increase inborn immunity.

In the USA, such experiments were not conducted either.

Who is interested to have a flu vaccine for 10 cents, if billions are spent on its creation?

Four children of Mikhail Chumakov and his wife, Marina Voroshilova, who was also a famous virologist and, in fact, suggested using OPV against other diseases, followed in the footsteps of her parents. Two is now in Russia, two are abroad. Konstantin Chumakov, who emigrated in the 89th, holds the post of deputy director for science in the vaccine department in the FDA.

With the beginning of the coronavirus epidemic, the famous American virologist Dr. Robert Gallo, known as the opener of HIV, and Konstantin Chumakov was proposed to use OPV as an “intermediate” vaccine.

The essence of their proposals is simple. The body, roughly speaking, can exist in normal mode - or can go into protective mode, feeling the presence of a virus, and a “living” vaccine from poliomyelitis triggers this process. Interferon begins to be produced in the body, which spreads through the body and triggers cascades that activate the operation of genes that direct the production of antiviral proteins. There are many antiviral proteins, and in order to describe their work here, you need not a separate article, but a separate monograph. But in general, they turn off the processes in a cage, without which the virus cannot multiply, or simply destroy RNA - including their own. The cell uses the tactics of scorched land. She will then restore her RNA, but the virus will die during this time. “The state of increased resistance to microbes is not optimal for other processes. After all, sooner or later the cell will need to restore its RNA and turn on all the processes again. This is the whole idea - to turn on the reserve mode for the fight against the virus for some time, ”says Chumakov.

It is very likely that OPV mobilizes the body the next day after vaccination (in any case, the virus in the feces is found the next day). There are practically no contraindications for use. If the child is unvaccinated by the Polio risks getting sick in one of the 800 thousand cases, then a person already vaccinated against poliomyelitis does not matter, a lively or dead vaccine, will not be generated to the polio of antibodies and can not get sick , except in the event of some unprecedented loss of immunity.

OPV, used in time, will help to protect for several weeks at least the most vulnerable and most important group in the struggle against coronavirus - that is, doctors.

From the OPV, the hospitals will cease to turn into hubs for infection, and the doctors themselves will cease to get out of order.

And at the same time, we are talking about a vaccine that already exists, is already widely used, costs 10 dose cents, does not need to be introduced in sterile syringes and can be used tomorrow.

It is noteworthy that in the democratic USA, it is very difficult to apply this vaccine on time to stop the epidemic. The trials that are now organizing Dr. Gallo and Chumaks require too much coordination, and therefore is very expensive.

These, in fact, are those approvals and permits that Mikhail Chumakov by his call Mikoyan by once bypassed. This is one of the few advantages of the authoritarian system over the democratic. In the authoritarian system in a critical situation, if someone reaches the head of the boss, and the boss will bargain: "To vaccinate!" - They can be vaccinated tomorrow.

OPV may well be the changer of the rules of the game that all politicians in the world dream of now.

The algorithm of actions here is very simple. It is necessary to start mass tests of OPV as a temporary vaccine from coronavirus. Since mass trials imply the presence of a group that is systematically dangered by infection, only doctors can be such a group.

Having ordered the trial of OPV in clinics tomorrow (that is, to actually apply it in three quarters of hospitals, and leave a quarter to the control), the Kremlin or the Moscow City Hall can actually radically change the course of the epidemic and solve the problem with the protection of doctors, without resorting to a lie or to PR.

Such a solution can really cause envy and amazement of the world.

Unless, of course, in Russia there is an Anastas Mikoyan in Russia again.